A collection of genomics, functional genomics, and
genetics studies and links to their resulting datasets. This resource describes
project scope, material, and objectives and provides a mechanism to retrieve
datasets that are often difficult to find due to inconsistent annotation,
multiple independent submissions, and the varied nature of diverse data types
which are often stored in different databases.
The BioSample database contains descriptions of
biological source materials used in experimental assays.
A collaborative effort to identify a core set of human
and mouse protein coding regions that are consistently annotated and of high
quality.
A divison of GenBank that contains short single-pass
reads of cDNA (transcript) sequences. dbEST can be searched directly through
the Nucleotide EST Database.
A division of GenBank that contains short single-pass
reads of genomic DNA. dbGSS can be searched directly through the Nucleotide GSS
Database.
Includes single nucleotide variations,
microsatellites, and small-scale insertions and deletions. dbSNP contains
population-specific frequency and genotype data, experimental conditions,
molecular context, and mapping information for both neutral variations and
clinical mutations.
The NIH genetic sequence database, an annotated
collection of all publicly available DNA sequences. GenBank is part of the
International Nucleotide Sequence Database Collaboration, which comprises the
DNA DataBank of Japan (DDBJ), the European Molecular Biology Laboratory (EMBL),
and GenBank at NCBI. These three organizations exchange data on a daily basis.
GenBank consists of several divisions, most of which can be accessed through
the Nucleotide database. The exceptions are the EST and GSS divisions, which
are accessed through the Nucleotide EST and Nucleotide GSS databases,
respectively.
A compilation of data from the NIAID Influenza Genome
Sequencing Project and GenBank. It provides tools for flu sequence
analysis, annotation and submission to GenBank. This resource also has links to
other flu sequence resources, and publications and general information about
flu viruses.
A collection of nucleotide sequences from several
sources, including GenBank, RefSeq, the Third Party Annotation (TPA) database,
and PDB. Searching the Nucleotide Database will yield available results from
each of its component databases.
Database of related DNA sequences that originate from
comparative studies: phylogenetic, population, environmental and, to a lesser
degree, mutational. Each record in the database is a set of DNA sequences. For
example, a population set provides information on genetic variation within an
organism, while a phylogenetic set may contain sequences, and their alignment,
of a single gene obtained from several related organisms.
A public registry of nucleic acid reagents designed
for use in a wide variety of biomedical research applications, together with
information on reagent distributors, probe effectiveness, and computed sequence
similarities.
A collection of human gene-specific reference genomic
sequences. RefSeq gene is a subset of NCBI’s RefSeq database, and are
defined based on review from curators of locus-specific databases and the
genetic testing community. They form a stable foundation for reporting
mutations, for establishing consistent intron and exon numbering conventions,
and for defining the coordinates of other biologically significant variation. RefSeqGene
is a part of the Locus Reference Genomic
(LRG)
Collaboration.
A collection of curated, non-redundant genomic DNA,
transcript (RNA), and protein sequences produced by NCBI. RefSeqs provide a
stable reference for genome annotation, gene identification and
characterization, mutation and polymorphism analysis, expression studies, and
comparative analyses. The RefSeq collection is accessed through the Nucleotide
and Protein databases.
The Sequence Read Archive (SRA) stores sequencing data
from the next generation of sequencing platforms including Roche 454 GS
System®, Illumina Genome Analyzer®, Life Technologies AB SOLiD System®, Helicos
Biosciences Heliscope®, Complete Genomics®, and Pacific Biosciences SMRT®.
A database that contains sequences built from the
existing primary sequence data in GenBank. The sequences and corresponding
annotations are experimentally supported and have been published in a
peer-reviewed scientific journal. TPA records are retrieved through the
Nucleotide Database.
A repository of DNA sequence chromatograms (traces), base
calls, and quality estimates for single-pass reads from various large-scale
sequencing projects.
A database that provides sets of transcript sequences
that appear to come from the same transcription locus (gene or expressed
pseudogene), together with information on protein similarities, gene
expression, cDNA clone reagents, and genomic location.
This database contains libraries of Expressed Sequence
Tags (ESTs) organized by organism, tissue type and developmental stage.
A comprehensive database of sequence tagged sites
(STSs) derived from STS-based maps and other experiments. STSs are defined by
PCR primer pairs and are associated with additional information, such as
genomic position, genes, and sequences.
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